Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis.

ABSTRACT:

Background

Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem motor neuron disease for which currently there is no effective treatment. There is an urgent need to identify biomarkers to tackle the disease's complexity and help in early diagnosis, prognosis, and therapy. Extracellular vesicles (EVs) are nanostructures released by any cell type into body fluids. Their biophysical and biochemical characteristics vary with the parent cell's physiological and pathological state and make them an attractive source of multidimensional data for patient classification and stratification.

Methods

We analyzed plasma-derived EVs of ALS patients (n = 106) and controls (n = 96), and SOD1^G93A and TDP-43^Q331K mouse models of ALS. We purified plasma EVs

SUBMITTER: Pasetto L 

PROVIDER: S-EPMC8353748 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature