Maternal supply of cysteamine alleviates oxidative stress and enhances angiogenesis in porcine placenta.

ABSTRACT:

Background

Oxidative stress in placenta is associated with the occurrence of adverse pregnancy outcomes in sow, but there are few satisfactory treatment strategies for these conditions. This study investigated the potential of cysteamine (CS) as an antioxidant protectant for regulating the reproductive performance, redox status, and placental angiogenesis of sows.

Methods

The placental oxidative stress status and vascular density of piglets with different birth weights: < 1.0 kg (low birth weight, LBW) and 1.4-1.6 kg (normal birth weight, NBW) were evaluated, followed by allotting 84 sows to four treatments (n = 21) and feeding them with a basal diet supplemented with 0, 100, 300, or 500 mg/kg of CS from d 85 of gestation to d 21 of lactation, respectively. Placenta, serum,

SUBMITTER: Huang S 

PROVIDER: S-EPMC8353810 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature