Changes in total body fat and body mass index among children with juvenile dermatomyositis treated with high-dose glucocorticoids.

ABSTRACT:

Objective

High-dose glucocorticoids (GC) remain the primary therapy to induce remission in Juvenile Dermatomyositis (JDM). Studies of the natural history of GC associated weight gain in children are very limited, especially in the JDM population. This study aims to measure BMI changes in a cohort of JDM subjects over 60 months and to examine the changes in body composition by DXA.

Methods

We included all subjects with JDM who had 5 years of follow-up data and multiple DXA studies. BMI and total body fat (TBF) percentiles were calculated based on the CDC published percentile charts. To study the natural history of weight gain and TBF, we assessed the data at four-time points (T0 = baseline, T1 > 1.5 years, T2 = 1.51-3.49 years, T3 = 3.5-5 years).

Results

68 subjects (7

SUBMITTER: Khojah A 

PROVIDER: S-EPMC8353815 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature