Recent advances of m⁶A methylation modification in esophageal squamous cell carcinoma.

ABSTRACT: In recent years, with the development of RNA sequencing technology and bioinformatics methods, the epigenetic modification of RNA based on N⁶-methyladenosine (m⁶A) has gradually become a research hotspot in the field of bioscience. m⁶A is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs). m⁶A methylation modification can dynamically and reversibly regulate RNA transport, localization, translation and degradation through the interaction of methyltransferase, demethylase and reading protein. m⁶A methylation can regulate the expression of proto-oncogenes and tumor suppressor genes at the epigenetic modification level to affect tumor occurrence and metastasis. The morbidity and mortality of esophageal cancer (EC)

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8353866 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature