CCL23 suppresses liver cancer progression through the CCR1/AKT/ESR1 feedback loop.

ABSTRACT: With the ability to activate certain signaling pathways, chemokines and their receptors may facilitate tumor progression at key steps, including proliferation, immunomodulation, and metastasis. Nevertheless, their prognostic value and regulatory mechanism warrant thorough studies in liver cancer. Here, by screening the expression profiles of all known chemokines in independent liver cancer cohorts, we found that CCL23 was frequently downregulated at mRNA and protein levels in liver cancer. Decreased CCL23 correlated with shortened patient survival, enrichment of signatures related to cancer stem cell property, and metastatic potential. In addition to serving as a tumor suppressor through recruiting CD8⁺ T cell infiltration in liver cancer, CCL23 could repress cancer cell prolife

SUBMITTER: Meng J 

PROVIDER: S-EPMC8353945 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature