Heterogenous expression of endoglin marks advanced renal cancer with distinct tumor microenvironment fitness.

ABSTRACT: Intratumoral heterogeneity, including in clear cell renal cell carcinoma, is a potential cause of drug resistance and metastatic cancer progression. We specified the heterogeneous population marked by endoglin (also known as CD105) in a preclinical model of clear cell renal cell carcinoma progression. Highly malignant derivatives of human clear cell renal cell carcinoma OS-RC-2 cells were established as OS5Ks by serial orthotopic inoculation in our previous study. Expression of both ENG (encoding endoglin) mRNA and protein were heterogeneously upregulated in OS5Ks, and the endoglin-positive (ENG⁺ ) population exhibited growth dependency on endoglin in anchorage-independent cultures. Despite the function of endoglin as a type III receptor, transforming growth factor β and bone mo

SUBMITTER: Momoi Y 

PROVIDER: S-EPMC8353946 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature