Transcriptome analysis of molecular mechanisms underlying facial nerve injury repair in rats.

ABSTRACT: Although the transcriptional alterations inside the facial nucleus after facial nerve injury have been well studied, the gene expression changes in the facial nerve trunk after injury are still unknown. In this study, we established an adult rat model of facial nerve crush injury by compressing the right lateral extracranial nerve trunk. Transcriptome sequencing, differential gene expression analysis, and cluster analysis of the injured facial nerve trunk were performed, and 39 intersecting genes with significant variance in expression were identified. Gene Ontology annotation and Kyoto Encyclopedia of Genes and Genomes pathway analyses of the 39 intersecting genes revealed that these genes are mostly involved in leukocyte cell-cell adhesion and phagocytosis and have essential roles in reg

SUBMITTER: Cao QQ 

PROVIDER: S-EPMC8354104 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature