Apelin-13 regulates electrical activity in the globus pallidus and induces postural changes in rats.

ABSTRACT: The globus pallidus is the relay nucleus of the basal ganglia, and changes in its electrical activity can cause motor impairment. Apelin-13 is widely distributed in the central and peripheral nervous systems. It has been demonstrated that apelin-13 plays important roles in the regulation of blood pressure and other non-motor functions. However, its role in motor function has rarely been reported. In the present study, apelin-13 (10 μM/100 μM) was injected into the globus pallidus of rats. The results showed that apelin-13 increased the spontaneous discharges in the majority of pallidal neurons. However, an apelin-13-induced inhibitory effect on the firing rate was also observed in a few pallidal neurons. In postural tests, after the systemic administration of haloperidol, unilateral pallid

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8354122 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature