Mesenchymal stem cell treatment for peripheral nerve injury: a narrative review.

ABSTRACT: Peripheral nerve injuries occur as the result of sudden trauma and lead to reduced quality of life. The peripheral nervous system has an inherent capability to regenerate axons. However, peripheral nerve regeneration following injury is generally slow and incomplete that results in poor functional outcomes such as muscle atrophy. Although conventional surgical procedures for peripheral nerve injuries present many benefits, there are still several limitations including scarring, difficult accessibility to donor nerve, neuroma formation and a need to sacrifice the autologous nerve. For many years, other therapeutic approaches for peripheral nerve injuries have been explored, the most notable being the replacement of Schwann cells, the glial cells responsible for clearing out debris from the

SUBMITTER: Zhang RC 

PROVIDER: S-EPMC8354135 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature