Association between cytokine levels, sepsis severity and clinical outcomes in sepsis: a quantitative systematic review protocol.

ABSTRACT:

Introduction

It is widely assumed that sepsis is a life-threatening systemic inflammation caused by a dysregulated host response to infection mediated by an increase in multiple proinflammatory cytokines. The levels of key proinflammatory cytokines tumour necrosis factor, interleukin-1β and interferon γ are poorly characterised during sepsis. We believe this project will produce a 'gold-standard' document to which other reports on cytokine levels will be compared. The objective of this systematic review will be to identify key cytokine circulating levels in patients with sepsis and assess the association between these levels and morbidity and mortality outcomes related to sepsis.

Methods and analysis

We would include reports of any design except for case reports. Seps

SUBMITTER: Gharamti A 

PROVIDER: S-EPMC8354287 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature