Neuropathic Injury-Induced Plasticity of GABAergic System in Peripheral Sensory Ganglia.

ABSTRACT: GABA is a major inhibitory neurotransmitter in the mammalian central nervous system (CNS). Inhibitory GABA_A channel circuits in the dorsal spinal cord are the gatekeepers of the nociceptive input from the periphery to the CNS. Weakening of these spinal inhibitory mechanisms is a hallmark of chronic pain. Yet, recent studies have suggested the existence of an earlier GABAergic "gate" within the peripheral sensory ganglia. In this study, we performed systematic investigation of plastic changes of the GABA-related proteins in the dorsal root ganglion (DRG) in the process of neuropathic pain development. We found that chronic constriction injury (CCI) induced general downregulation of most GABA_A channel subunits and the GABA-producing enzyme, glutamate decarboxylase, cons

SUBMITTER: Wang C 

PROVIDER: S-EPMC8354334 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature