Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders.

ABSTRACT: Dystonia is a neurological disorder characterized by sustained or intermittent muscle contractions causing abnormal movements and postures, often occurring in absence of any structural brain abnormality. Psychiatric comorbidities, including anxiety, depression, obsessive-compulsive disorder and schizophrenia, are frequent in patients with dystonia. While mutations in a fast-growing number of genes have been linked to Mendelian forms of dystonia, the cellular, anatomical, and molecular basis remains unknown for most genetic forms of dystonia, as does its genetic and biological relationship to neuropsychiatric disorders. Here we applied an unbiased systems-biology approach to explore the cellular specificity of all currently known dystonia-associated genes, predict their functional relations

SUBMITTER: Mencacci NE 

PROVIDER: S-EPMC8354373 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature