CIDEC silencing attenuates diabetic nephropathy via inhibiting apoptosis and promoting autophagy.

ABSTRACT:

Objective

The role of cell death-inducing DFF45-like effector C (CIDEC) in insulin resistance has been established, and it is considered to be an important trigger factor for the progression of diabetic nephropathy (DN). We intend to explore whether CIDEC plays an important role in the regulation of DN and its potential mechanism.

Methods

High-fat diet and low dose streptozotocin were used to establish type 2 diabetic rat model. We investigate the role of CIDEC in the pathogenesis and process of DN through histopathological analysis, western blot and gene silencing. Meanwhile, the effect of CIDEC on renal tubular epithelial cells stimulated by high glucose was also verified.

Results

DM group exhibited glucose and lipid metabolic disturbance, with hypertrophy of kidney

SUBMITTER: Zheng GS 

PROVIDER: S-EPMC8354488 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature