Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment.

ABSTRACT:

Aims/introduction

Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans. However, limited information is known about plasma XOR activity in patients with type 2 diabetes mellitus, and its changes after short-term glycemic control treatment.

Materials and methods

We enrolled 28 Japanese patients (10 men/18 women) with type 2 diabetes mellitus who were hospitalized to undergo medical treatment for diabetes. Plasma XOR activity, quantified using triple quadrupole mass spectrometry and liquid chromatography, and other clinical parameters were examined at admission and 2 weeks after treatment during hospitalization. Changes in plasma XOR activity after t

SUBMITTER: Kawachi Y 

PROVIDER: S-EPMC8354500 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature