PKD2/polycystin-2 induces autophagy by forming a complex with BECN1.

ABSTRACT: Macroautophagy/autophagy is an intracellular process involved in the breakdown of macromolecules and organelles. Recent studies have shown that PKD2/PC2/TRPP2 (polycystin 2, transient receptor potential cation channel), a nonselective cation channel permeable to Ca²⁺ that belongs to the family of transient receptor potential channels, is required for autophagy in multiple cell types by a mechanism that remains unclear. Here, we report that PKD2 forms a protein complex with BECN1 (beclin 1), a key protein required for the formation of autophagic vacuoles, by acting as a scaffold that interacts with several co-modulators via its coiled-coil domain (CCD). Our data identified a physical and functional interaction between PKD2 and BECN1, which depends on one out of two CCD domains (C

SUBMITTER: Pena-Oyarzun D 

PROVIDER: S-EPMC8354594 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature