Ontology highlight
ABSTRACT:
SUBMITTER: Tessadori F
PROVIDER: S-EPMC8354640 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Tessadori Federico F Tsingos Erika E Colizzi Enrico Sandro ES Kruse Fabian F van den Brink Susanne C SC van den Boogaard Malou M Christoffels Vincent M VM Merks Roeland Mh RM Bakkers Jeroen J
eLife 20210810
Organ laterality refers to the left-right asymmetry in disposition and conformation of internal organs and is established during embryogenesis. The heart is the first organ to display visible left-right asymmetries through its left-sided positioning and rightward looping. Here, we present a new zebrafish loss-of-function allele for <i>tbx5a</i>, which displays defective rightward cardiac looping morphogenesis. By mapping individual cardiomyocyte behavior during cardiac looping, we establish that ...[more]