The Selective Dopamine D2 Blocker Sulpiride Modulates the Relationship Between Agentic Extraversion and Executive Functions.

ABSTRACT: Initial studies suggest that agentic extraversion and executive functions (EF) are associated, because they share influences of individual differences in the dopamine (DA) system. However, it is unclear whether previously reported associations are specific to certain EFs (e.g., to updating or shifting) or due to shared variance among EF tasks. We investigated the DA-related relationship between agentic extraversion and two EF tasks in a placebo-controlled between-group design with the DA D2 receptor blocker sulpiride (200 mg) in 92 female volunteers. Our goals were to investigate whether (1) there is an association between agentic extraversion and EFs measured with two different tasks (3-back and switching), (2) this association is sensitive to a pharmacological manipulation of DA, and (3)

SUBMITTER: Herrmann W 

PROVIDER: S-EPMC8354875 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature