Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients.

ABSTRACT:

Purpose

Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients.

Methods

Concentrations of 134 metabolites of the Biocrates Absolute^IDQ p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were use

SUBMITTER: Geijsen AJMR 

PROVIDER: S-EPMC8354955 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature