Studies of the role of basophils in aspirin-exacerbated respiratory disease pathogenesis.

ABSTRACT:

Background

Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and intolerance to cyclooxygenase-1 enzyme inhibitors. The underlying mechanisms contributing to AERD pathogenesis are not fully understood, but AERD is characterized by an enhanced type 2 inflammatory phenotype. Basophils are potent type 2 effector cells, but their involvement in AERD pathophysiology remains unclear.

Objective

We sought to characterize the systemic and local basophil responses in patients with AERD compared with patients with CRSwNP.

Methods

Sinonasal tissues including inferior turbinate and/or nasal polyps (NPs) and peripheral blood were collected from controls, patients with AERD, and patients with CR

SUBMITTER: Stevens WW 

PROVIDER: S-EPMC8355049 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature