Association between obesity and neurocognitive function in survivors of childhood acute lymphoblastic leukemia treated only with chemotherapy.

ABSTRACT:

Background

Neurocognitive impairment and obesity are common adverse sequelae in survivors of childhood acute lymphoblastic leukemia (ALL); however, the association has not been investigated.

Methods

Neurocognitive function was evaluated once in survivors of ALL who were at least 8 years old and 5 years from their diagnosis. In a cross-sectional analysis, the associations with the body mass index (BMI) category and Z score were examined. A longitudinal analysis used the overweight/obesity area under the curve (AUC), which was determined via the trapezoidal rule by a sum of the integrals defined by the BMI Z score at each time point and the time intervals of the BMI measurement.

Results

For 210 survivors, the median BMI Z score at diagnosis was 0.17, which increased to

SUBMITTER: Iijima M 

PROVIDER: S-EPMC8355093 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature