Theta-phase dependent neuronal coding during sequence learning in human single neurons.

ABSTRACT: The ability to maintain a sequence of items in memory is a fundamental cognitive function. In the rodent hippocampus, the representation of sequentially organized spatial locations is reflected by the phase of action potentials relative to the theta oscillation (phase precession). We investigated whether the timing of neuronal activity relative to the theta brain oscillation also reflects sequence order in the medial temporal lobe of humans. We used a task in which human participants learned a fixed sequence of pictures and recorded single neuron and local field potential activity with implanted electrodes. We report that spikes for three consecutive items in the sequence (the preferred stimulus for each cell, as well as the stimuli immediately preceding and following it) were phase-locked

SUBMITTER: Reddy L 

PROVIDER: S-EPMC8355141 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature