Population pharmacokinetics and pharmacodynamics of Tranexamic acid in women undergoing caesarean delivery.

ABSTRACT:

Aims

The population pharmacokinetics (PK) and pharmacodynamics (PD) of tranexamic acid (TXA) have not been studied to prevent postpartum haemorrhage (PPH) in pregnant women. It is unclear which TXA dose assures sufficient PPH prevention. This study investigated population PK/PD of TXA in pregnant women who underwent caesarean delivery to determine the optimal prophylactic doses of TXA for future studies.

Methods

We analysed concentration (PK) and maximum lysis (PD) data from 30 pregnant women scheduled for caesarean delivery who received 5, 10 or 15 mg/kg of TXA intravenously using population approach.

Results

TXA PK was best described by a two-compartment model with first-order elimination and the following parameters: clearance (between-subject variability) of 9.4 L

SUBMITTER: Li S 

PROVIDER: S-EPMC8355246 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature