Choice-relevant information transformation along a ventrodorsal axis in the medial prefrontal cortex.

ABSTRACT: Choice-relevant brain regions in prefrontal cortex may progressively transform information about options into choices. Here, we examine responses of neurons in four regions of the medial prefrontal cortex as macaques performed two-option risky choices. All four regions encode economic variables in similar proportions and show similar putative signatures of key choice-related computations. We provide evidence to support a gradient of function that proceeds from areas 14 to 25 to 32 to 24. Specifically, we show that decodability of twelve distinct task variables increases along that path, consistent with the idea that regions that are higher in the anatomical hierarchy make choice-relevant variables more separable. We also show progressively longer intrinsic timescales in the same series. To

SUBMITTER: Maisson DJ 

PROVIDER: S-EPMC8355277 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature