Psychometric validation of the Hypoparathyroidism Patient Experience Scales (HPES).

ABSTRACT:

Background

Hypoparathyroidism (HP) is a rare endocrine disorder characterized by absent or inappropriately low levels of circulating parathyroid hormone with associated significant physical and cognitive symptoms. This study evaluated the psychometric properties of the Hypoparathyroidism Patient Experience Scales (HPES), which were developed as disease-specific, patient-reported outcome (PRO) measures to assess the symptoms and impacts associated with HP in adults.

Methods

Data from a non-interventional, observational study (N = 300) and a Phase 2 clinical trial (N = 59) were used in the psychometric evaluation. Observational and trial assessments included: an online validation battery (baseline or screening) and retest (approximately 2 weeks after baseline or screening). In

SUBMITTER: Brod M 

PROVIDER: S-EPMC8355305 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature