Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.

ABSTRACT: Hippocampal pyramidal cells encode an animal's location by single action potentials and complex spike bursts. These elementary signals are believed to play distinct roles in memory consolidation. The timing of single spikes and bursts is determined by intrinsic excitability and theta oscillations (5-10 Hz). Yet contributions of these dynamics to place fields remain elusive due to the lack of methods for specific modification of burst discharge. In mice lacking Kcnq3-containing M-type K⁺ channels, we find that pyramidal cell bursts are less coordinated by the theta rhythm than in controls during spatial navigation, but not alert immobility. Less modulated bursts are followed by an intact post-burst pause of single spike firing, resulting in a temporal discoordination of network o

SUBMITTER: Gao X 

PROVIDER: S-EPMC8355348 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature