Ceftazidime-Avibactam for the Treatment of Serious Gram-Negative Infections with Limited Treatment Options: A Systematic Literature Review.

ABSTRACT:

Introduction

A systematic literature review was undertaken to evaluate real-world use of ceftazidime-avibactam for infections due to aerobic Gram-negative organisms in adults with limited treatment options.

Methods

Literature searches retrieved peer-reviewed publications and abstracts from major international infectious disease congresses from January 2015 to February 2021. Results were screened using pre-defined criteria to limit the dataset to relevant publications (notable exclusions were paediatric data and outcomes data for bacteria intrinsically resistant to ceftazidime-avibactam). Data for included publications were subjected to qualitative synthesis.

Results

Seventy-three relevant publications (62 peer-reviewed articles; 10 abstracts) comprising 1926 patients

SUBMITTER: Soriano A 

PROVIDER: S-EPMC8355581 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature