Probing Synergistic Targets by Natural Compounds for Hepatocellular Carcinoma.

ABSTRACT:

Background

Designing combination drugs for malignant cancers has been restricted due to the scarcity of synergy-medicated targets, while some natural compounds have demonstrated potential to enhance anticancer effects.

Methods

We here explored the feasibility of probing synergy-mediated targets by Berberine (BER) and Evodiamine (EVO) in hepatocellular carcinoma (HCC). Using the genomics-derived HCC signaling networks of compound treatment, NF-κB and c-JUN were inferred as key responding elements with transcriptional activity coinhibited during the synergistic cytotoxicity induction in BEL-7402 cells. Then, selective coinhibitors of NF-κB and c-JUN were tested demonstrating similar synergistic antiproliferation activity.

Results

Consistent with in vivo experimen

SUBMITTER: Gao J 

PROVIDER: S-EPMC8355820 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature