Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health.

ABSTRACT:

Objectives

Regular physical exercise improves health by reducing the risk of a plethora of chronic disorders. We hypothesized that endurance exercise training remodels the activity of gene enhancers in skeletal muscle and that this remodeling contributes to the beneficial effects of exercise on human health.

Methods and results

By studying changes in histone modifications, we mapped the genome-wide positions and activities of enhancers in skeletal muscle biopsies collected from young sedentary men before and after 6 weeks of endurance exercise. We identified extensive remodeling of enhancer activities after exercise training, with a large subset of the remodeled enhancers located in the proximity of genes transcriptionally regulated after exercise. By overlapping the positio

SUBMITTER: Williams K 

PROVIDER: S-EPMC8355925 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature