Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity.

ABSTRACT:

Objective

Recent studies suggest that hypoxia exposure may improve glucose homeostasis, but well-controlled human studies are lacking. We hypothesized that mild intermittent hypoxia (MIH) exposure decreases tissue oxygen partial pressure (pO₂) and induces metabolic improvements in people who are overweight/obese.

Methods

In a randomized, controlled, single-blind crossover study, 12 men who were overweight/obese were exposed to MIH (15 % O₂, 3 × 2 h/day) or normoxia (21 % O₂) for 7 consecutive days. Adipose tissue (AT) and skeletal muscle (SM) pO₂, fasting/postprandial substrate metabolism, tissue-specific insulin sensitivity, SM oxidative capacity, and AT and SM gene/protein expression were determined. Furthermore, primary human my

SUBMITTER: van Meijel RLJ 

PROVIDER: S-EPMC8355948 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature