Reversibility of Antipsychotic-Induced Weight Gain: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background and aims

Weight gain is a major adverse effect of antipsychotic medication, negatively affecting physical and mental well-being. The objective of this study was to explore if dose reduction, discontinuation, switch to a partial agonist, or switch from polypharmacy to monotherapy will lead to weight loss.

Methods

Controlled and uncontrolled studies reporting the effects of discontinuation, dose reduction, switch to a partial agonist, or switch from polypharmacy to monotherapy on weight were included. Primary outcome was difference in weight compared to maintenance groups based on controlled studies. Secondary outcome was change in weight from initiation of one of the included interventions until follow-up in a pre-post analysis.

Results

We identified 40 rand

SUBMITTER: Speyer H 

PROVIDER: S-EPMC8355990 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature