Association Between Weight Change and Leukocyte Telomere Length in U.S. Adults.

ABSTRACT:

Objective

To investigate the association of dynamic weight change in adulthood with leukocyte telomere length among U.S. adults.

Methods

This study included 3,886 subjects aged 36-75 years from the National Health and Nutrition Examination Survey (NHANES) 1999-2002 cycle. Survey-weighted multivariable linear regression with adjustments for potential confounders was utilized.

Results

3,386 individuals were finally included. People with stable obesity had a 0.130 kbp (95% CI: 0.061-0.198, P=1.97E-04) shorter leukocyte telomere length than those with stable normal weight (reference group) during the 10-year period, corresponding to approximately 8.7 years of aging. Weight gain from non-obesity to obesity shortened the leukocyte telomere length by 0.094 kbp (95% CI

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8355991 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature