Ontology highlight
ABSTRACT:
SUBMITTER: Judson R
PROVIDER: S-EPMC8356084 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Judson Richard R Houck Keith K Paul Friedman Katie K Brown Jason J Browne Patience P Johnston Paul A PA Close David A DA Mansouri Kamel K Kleinstreuer Nicole N
Regulatory toxicology and pharmacology : RTP 20200814
Screening certain environmental chemicals for their ability to interact with endocrine targets, including the androgen receptor (AR), is an important global concern. We previously developed a model using a battery of eleven in vitro AR assays to predict in vivo AR activity. Here we describe a revised mathematical modeling approach that also incorporates data from newly available assays and demonstrate that subsets of assays can provide close to the same level of predictivity. These subset models ...[more]