Tumor microenvironment evaluation promotes precise checkpoint immunotherapy of advanced gastric cancer.

ABSTRACT:

Background

Durable efficacy of immune checkpoint blockade (ICB) occurred in a small number of patients with metastatic gastric cancer (mGC) and the determinant biomarker of response to ICB remains unclear.

Methods

We developed an open-source TMEscore R package, to quantify the tumor microenvironment (TME) to aid in addressing this dilemma. Two advanced gastric cancer cohorts (RNAseq, N=45 and NanoString, N=48) and other advanced cancer (N=534) treated with ICB were leveraged to investigate the predictive value of TMEscore. Simultaneously, multi-omics data from The Cancer Genome Atlas of Stomach Adenocarcinoma (TCGA-STAD) and Asian Cancer Research Group (ACRG) were interrogated for underlying mechanisms.

Results

The predictive capacity of TMEscore was corroborated in p

SUBMITTER: Zeng D 

PROVIDER: S-EPMC8356190 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature