The role of microbiota in allogeneic hematopoietic stem cell transplantation.

ABSTRACT:

Introduction

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is commonly performed to treat a variety of benign and malignant hematological diseases. Acute graft-versus-host disease (GVHD) is a major life-threatening complication that often occurs following allo-HSCT. Recently, improvements in methods to characterize the microbiota have led to a greater appreciation for how frequently and profoundly an alteration in microbial composition, or dysbiosis, can occur in allo-HSCT recipients to better decipher the complex interplay between microbiota and allo-HSCT outcomes.

Areas covered

This article reviews the current knowledge of the microbiota's impact on allo-HSCT outcomes, including effects of microbiota-derived metabolites, and crosstalk between commensals an

SUBMITTER: Chang CC 

PROVIDER: S-EPMC8356441 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature