Prognostic significance of high metabolic activity in breast cancer: PET signature in breast cancer.

ABSTRACT: High metabolic activity, reflected in increased glucose uptake, is one of the hallmarks of many cancers including breast cancer. However, not all cancers avidly take up glucose, suggesting heterogeneity in their metabolic demand. Thus, we aim to generate a genomic signature of glucose hypermetabolism in breast cancer and examine its clinical relevance. To identify genes significantly associated with glucose uptake, gene expression data were analyzed together with the standardized uptake values (SUVmax) of ¹⁸F-fluorodeoxy-glucose on positron emission tomography (PET) for 11 breast cancers. The resulting PET signature was evaluated for prognostic significance in four large independent patient cohorts (n = 5417). Potential upstream regulators accountable for the high glucose uptake

SUBMITTER: Kang S 

PROVIDER: S-EPMC8356554 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature