Expert-Augmented Computational Drug Repurposing Identified Baricitinib as a Treatment for COVID-19.

ABSTRACT: The onset of the 2019 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic necessitated the identification of approved drugs to treat the disease, before the development, approval and widespread administration of suitable vaccines. To identify such a drug, we used a visual analytics workflow where computational tools applied over an AI-enhanced biomedical knowledge graph were combined with human expertise. The workflow comprised rapid augmentation of knowledge graph information from recent literature using machine learning (ML) based extraction, with human-guided iterative queries of the graph. Using this workflow, we identified the rheumatoid arthritis drug baricitinib as both an antiviral and anti-inflammatory therapy. The effectiveness of baricitinib was substantiated b

SUBMITTER: Smith DP 

PROVIDER: S-EPMC8356560 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature