CD169 Defines Activated CD14⁺ Monocytes With Enhanced CD8⁺ T Cell Activation Capacity.

ABSTRACT: Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or regulating inflammatory responses, but their role in T cell stimulation is not well defined. In inflammatory conditions, monocytes frequently show increased expression of CD169/Siglec-1, a type-I interferon (IFN-I)-regulated protein. However, little is known about the phenotype and function of these CD169⁺ monocytes. Here, we have investigated the phenotype of human CD169⁺ monocytes in different diseases, their capacity to activate CD8⁺ T cells, and the potential for a targeted-vaccination approach. Using spectral flow cytometry, we detected CD169 expression by CD14⁺ CD16^- classical and CD14⁺ CD16⁺ intermediate monocytes and unbi

SUBMITTER: Affandi AJ 

PROVIDER: S-EPMC8356644 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature