Diffusion-informed spatial smoothing of fMRI data in white matter using spectral graph filters.

ABSTRACT: Brain activation mapping using functional magnetic resonance imaging (fMRI) has been extensively studied in brain gray matter (GM), whereas in large disregarded for probing white matter (WM). This unbalanced treatment has been in part due to controversies in relation to the nature of the blood oxygenation level-dependent (BOLD) contrast in WM and its detectability. However, an accumulating body of studies has provided solid evidence of the functional significance of the BOLD signal in WM and has revealed that it exhibits anisotropic spatio-temporal correlations and structure-specific fluctuations concomitant with those of the cortical BOLD signal. In this work, we present an anisotropic spatial filtering scheme for smoothing fMRI data in WM that accounts for known spatial constraints on th

SUBMITTER: Abramian D 

PROVIDER: S-EPMC8356807 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature