Graph theoretical analysis of evoked potentials shows network influence of epileptogenic mesial temporal region.

ABSTRACT: It is now widely accepted that seizures arise from the coordinated activity of epileptic networks, and as a result, traditional methods of analyzing seizures have been augmented by techniques like single-pulse electrical stimulation (SPES) that estimate effective connectivity in brain networks. We used SPES and graph analytics in 18 patients undergoing intracranial EEG monitoring to investigate effective connectivity between recording sites within and outside mesial temporal structures. We compared evoked potential amplitude, network density, and centrality measures inside and outside the mesial temporal region (MTR) across three patient groups: focal epileptogenic MTR, multifocal epileptogenic MTR, and non-epileptogenic MTR. Effective connectivity within the MTR had significantly greater

SUBMITTER: Hays MA 

PROVIDER: S-EPMC8356982 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature