Racial differences in the risk of second primary bladder cancer following radiation therapy among localized prostate cancer patients.

ABSTRACT:

Objectives

To investigate the race-specific second primary bladder cancer (SPBC) risk following prostatic irradiation.

Methods

Louisiana residents who were diagnosed with localized prostate cancer (PCa) in 1996-2013 and received surgery or radiation were included. Patients were followed until SPBC diagnosis, death, or Dec. 2018. The exposure variable was type of treatment (radiation only vs. surgery only). The outcome was time from PCa diagnosis to SPBC diagnosis, stratified by race. Fine and Gray's competing risk model was applied with death as a competing event and adjustment of sociodemographic and tumor characteristics. We used 5 years and 10 years as lag time in the analyses.

Results

A total of 26,277 PCa patients with a median follow-up of 10.7 years were analyz

SUBMITTER: Zhang L 

PROVIDER: S-EPMC8357014 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature