Cognitive Resilience to Alzheimer's Disease Pathology in the Human Brain.

ABSTRACT:

Background

Past research has focused on risk factors for developing dementia, with increasing recognition of "resilient" people who live to old age with intact cognitive function despite pathological features of Alzheimer's disease (AD).

Objective

To evaluate demographic factors, mid-life characteristics, and non-AD neuropathology findings that may be associated with cognitive resilience to AD pathology.

Methods

We analyzed data from 276 autopsy cases with intermediate or high levels of AD pathology from the Adult Changes in Thought study. We defined cognitive resilience as having Cognitive Abilities Screening Instrument scores ≥86 within two years of death and no clinical dementia diagnosis; non-resilient people had dementia diagnoses from AD or other causes before d

SUBMITTER: Aiello Bowles EJ 

PROVIDER: S-EPMC8357030 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature