Production of copper-64 using a hospital cyclotron: targetry, purification and quality analysis.

ABSTRACT:

Objectives

To construct and evaluate a 64Cu production system that minimises the amount of costly 64Ni, radionuclidic impurities and nonradioactive metal contamination and maximises radiochemical and radionuclidic purity and molar activity; and to report analytical and quality control methods that can be used within typical PET radiochemistry production facilities to measure metal ion concentrations and radiometal molar activities.

Methods

Low volume was ensured by dissolving the irradiated nickel in a low volume of hydrochloric acid (<1 mL) using the concave gold target backing as a reaction vessel in a custom-built target holder. Removal of contaminating 55Co and nonradioactive trace metals was ensured by adding an intermediate hydrochloric acid concentration step during t

SUBMITTER: Jauregui-Osoro M 

PROVIDER: S-EPMC8357037 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature