Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.

ABSTRACT: During general anesthesia, both behavioral and autonomic changes are caused by the administration of anesthetics such as propofol. Propofol produces unconsciousness by creating highly structured oscillations in brain circuits. The anesthetic also has autonomic effects due to its actions as a vasodilator and myocardial depressant. Understanding how autonomic dynamics change in relation to propofol-induced unconsciousness is an important scientific and clinical question since anesthesiologists often infer changes in level of unconsciousness from changes in autonomic dynamics. Therefore, we present a framework combining physiology-based statistical models that have been developed specifically for heart rate variability and electrodermal activity with a robust statistical tool to compare behav

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC8357089 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature