Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages.

ABSTRACT: The intestinal nematode parasite Trichuris muris dwells in the caecum and proximal colon driving an acute resolving intestinal inflammation dominated by the presence of macrophages. Notably, these macrophages are characterised by their expression of RELMα during the resolution phase of the infection. The RELMα+ macrophage phenotype associates with the presence of alternatively activated macrophages and work in other model systems has demonstrated that the balance of classically and alternatively activated macrophages is critically important in enabling the resolution of inflammation. Moreover, in the context of type 2 immunity, RELMα+ alternatively activated macrophages are associated with the activation of macrophages via the IL4Rα. Despite a breadth of inflammatory pathologies associated

SUBMITTER: Forman R 

PROVIDER: S-EPMC8357096 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature