Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.

ABSTRACT: Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption and several cardiometabolic traits in the UK Biobank. Using the well-established ADH1B Arg47His variant (rs1229984) and up to 24 additional SNPs recently found to be associated with alcohol consumption in an independent dataset as instruments, we conducted two-stage least squares and inverse weighted variance MR analyses, both as one-sample analyses in the UK Biobank and as two-sample analyses in external consortia. In the UK Biobank inverse variance weighted analyses, we found that one addition

SUBMITTER: Lankester J 

PROVIDER: S-EPMC8357114 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature