Prognosis of amyotrophic lateral sclerosis with cognitive and behavioural changes based on a sixty-month longitudinal follow-up.

ABSTRACT:

Objective

Approximately 50% of amyotrophic lateral sclerosis (ALS) patients have cognitive and behavioural dysfunction in varying degrees and forms. Previous studies have shown that cognitive and behavioural changes may indicate a poor prognosis, and cognitive function gradually deteriorates over the course of disease, but the results of different studies have been inconsistent. In addition, there are relatively limited long-term follow-up studies tracking death as an endpoint. The purpose of this study was to investigate the clinical prognostic characteristics of ALS patients with cognitive behavioural changes through long-term follow-up in a cohort.

Methods

A total of 87 ALS patients from 2014 to 2015 in the Third Hospital of Peking University were selected and divided int

SUBMITTER: Ye S 

PROVIDER: S-EPMC8357115 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature