Long-term mucosal T cell activation and homing phenotypes in recipients of an Ad5-vectored HIV vaccine.

ABSTRACT:

Background

Vaccine-induced mucosal immune responses may be critical for protection against HIV infection, but may also result in short or long-term changes that enhance susceptibility to infection in some individuals, such as those with baseline seroreactivity to vaccine vector antigens. We examined cellular immune responses in blood and gut mucosal tissue roughly two years following vaccination with placebo or the Step study vaccine MRKAd5/HIV-1.

Methods

Participants vaccinated with either placebo or MRKAd5/HIV-1 during participation in HVTN 071, and HVTN 502/Merck 023 underwent phlebotomy and colonic mucosal biopsies via flexible sigmoidoscopy at two timepoints roughly six months apart. After isolation of mononuclear cells, we compared cellular phenotypes and intracellular

SUBMITTER: Curlin ME 

PROVIDER: S-EPMC8357155 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature