Ontology highlight
ABSTRACT:
SUBMITTER: Wu L
PROVIDER: S-EPMC8357247 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wu Leqin L Qiu Xing X Yuan Ya-Xiang YX Wu Hulin H
Journal of the American Statistical Association 20180711 526
Ordinary differential equations (ODEs) are widely used to model the dynamic behavior of a complex system. Parameter estimation and variable selection for a "Big System" with linear ODEs are very challenging due to the need of nonlinear optimization in an ultra-high dimensional parameter space. In this article, we develop a parameter estimation and variable selection method based on the ideas of similarity transformation and separable least squares (SLS). Simulation studies demonstrate that the p ...[more]