Common single nucleotide polymorphisms in the FNDC5 gene and serum irisin levels in acute myocardial infarction.

ABSTRACT:

Objective

Acute myocardial infarction (AMI) is the most common type of coronary artery disease. The irisin hormone encoded by the fibronectin type III domain-containing protein-5 (FNDC5) gene is synthesized in muscle, heart, and fat tissues. The present study aims to investigate serum irisin concentrations and FNDC5 genetic variants in patients with AMI through comparison with controls.

Methods

This study included 225 patients with AMI and 225 healthy subjects. Blood samples were obtained from patients during the first 1-24 hours after AMI. Serum irisin concentration was measured with enzyme-linked immunosorbent assay (ELISA). The variants of rs16835198, rs3480, and rs726344 in the FNDC5 gene were genotyped with real time polymerase chain reaction (RT-PCR).

Results

Co

SUBMITTER: Onalan Etem E 

PROVIDER: S-EPMC8357437 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature