Impact of breast cancer risk factors on clinically relevant prognostic biomarkers for primary breast cancer.

ABSTRACT:

Purpose

In addition to impacting incidence, risk factors for breast cancer may also influence recurrence and survival from the disease. However, it is unclear how these factors affect combinatorial biomarkers for aiding treatment decision-making in breast cancer.

Methods

Patients were 8179 women with histologically confirmed invasive breast cancer, diagnosed and treated in a large cancer hospital in Beijing, China. Individual clinicopathological (tumor size, grade, lymph nodes) and immunohistochemical (IHC: ER, PR, HER2, KI67) markers were used to define clinically relevant combinatorial prognostic biomarkers, including the Nottingham Prognostic Index (NPI: combining size, grade, nodes) and IHC4 score (combining ER, PR, HER2, KI67). Odds ratios (ORs) and 95% confidence inter

SUBMITTER: Abubakar M 

PROVIDER: S-EPMC8357643 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature